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KMID : 0350519960490010437
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Journal of Catholic Medical College
1996 Volume.49 No. 1 p.437 ~ p.443
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The Effects of Local Irradiation on the Femoral Bone in Rats -Bone Mineral Density Evaluation-
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Abstract
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There have been many clinical and experimental studies regarding the effects of irradiation on the bone. In general, clinical and roentgenographic manifestations of bone damages or changes occur gradually in late stage. Plain radiography, bone
scintigraphy, computed tomography and magnetic resonance imaging can be used in order to evaluate bone changes, However, no study has been done concerning of bone mineral density by irradiation.
The purpose of this study is to evaluate the effects of local irradiation on the bone mineral density (BMD). Twenty four healthy rats were divided into 4 groups according to the dose of irradiation: 1000 cGy was irradiated to the right femurs of
12
rats
with protection of left femur and the left femurs were used as control; 3000 cGy to the right to femurs of 12 rats with protection of left femur and the left femurs as control. The bone mineral density was measured 1st day, 2nd week, 3rd week,
4th
week
and 6th week after irradiation.
@ES The results were as follows :
@EN 1. BMD in 3000 cGy irradiated femur was significantly lower than BMD in 1000 cGy irradiated femur and control of 3000 cGy irradiation (P<0.05).
2. BMD in 1000 cGy irradiated femur was not different compared with BMD in 1000 cGy (P>0.05).
3. BMD between controls of 1000 cGy and 3000 cGy was not different (P>0.05).
4. Histologically, no changes in the cortical bone was observed in control and 1000 cGy irradiation, but hyalinized and degenerated cortical bone was observed I 3000 cGy irradiation. Bone marrow revealed mild hemorrhagic necrosis and fat
replacement in
1000 cGy irradiation, and severe hemorrhagic necrosis in 3000 cGy irradiation.
The results suggest that local irradiation can affect the BMD of bone, as well as histologay of cortical bone and bone marrow. Radiation dosage might be an important factor affecting the BMD.
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KEYWORD
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